Dr. Sayeed’s research focuses on the potential of progesterone and its metabolites in the treatment of ischemic stroke and traumatic brain injury. He hopes to translate his work to clinical practice in treating stroke. A current translational, milestone-driven NINDS U01 award, “Progesterone in the Treatment of Ischemic Stroke,” which Dr. Sayeed is leading, is designed to meet the FDA requirements for an IND application to test progesterone in human stroke.
Under a Scientist Development Grant from the American Heart Association, he is evaluating combinations of progesterone, its metabolite allopregnanolone, and tPA in a rat model of embolic ischemic stroke. This project will complement translational studies on progesterone monotherapy, and will bring progesterone closer to clinical application for ischemic stroke.
He was invited to speak at the International Neuroscience 25th Summer School under the auspices of the Royal Netherlands Academy of Arts and Sciences and the Graduate School Neurosciences Amsterdam on “Progress in Restorative Neuroscience and Neurology." He has authored over 30 reviews and scientific papers in peer reviewed journals, and serves as reviewer for proposals submitted to American Institute of Biological Sciences (AIBS) Peer Review of Proposals submitted to the U.S. Army Medical Research and Materiel Command (USAMRMC) and for Veterans Administration merit review panel for their brain injury program.
As a scientific member of Emory IACUC for over five years he evaluates protocols, scientific merit and animal welfare issues.